Muscle Autoantibodies and Antigens

Wegener's granulomatosis and autoantibodies to neutrophil antigens

We report five cases of Wegener's granulomatosis all of whom had clinical and histological evidence of disease activity at presentation and in whom autoantibodies to neutrophil antigens were detected. This test may prove useful for the diagnosis of this serious condition and help to monitor disease activity during treatment.

Apoptotic antigens, B2-glycoprotein I, and antiphospholipid autoantibodies.

Autoantibodies to intracellular antigens: generation and pathogenetic role.

Autoantibodies to intracellular antigens form a large family of immunoglobulins directed to a variety of ubiquitously expressed intracellular molecules, including numerous enzymes, some ribonucleoproteins and double-stranded DNA. These anti-self antibodies have been found to be selectively expressed in sera of patients with several systemic (non-organ-specific) autoimmune diseases, such as syst...

The diagnostic problems in patient with ascites, elevated Ca 125 level and autoantibodies against nuclear antigens and smooth muscle antigens mimicking advanced ovarian carcinoma--case study.

The paper describes a case of 26-year-old patient primarily suspected to suffer from the ovarian or peritoneum cancer due to high level of Ca 125 antigen and ascites. During exploratory laparotomy, neoplastic process was excluded, which was confirmed by histopathological examination. Further diagnostic tests were performed. The patient was not infected with hepatitic B or C virus, and there was...

Autoantibodies targeting tumor-associated antigens in metastatic cancer

In addition to the well-established effector functions of IgGs, including direct cytotoxicity and antibody-dependent cellular cytotoxicity, some populations of IgGs may exert anti-inflammatory effects. Here, we describe a population of antibodies that form in the natural course of metastatic cancer and contain glycans that terminate with sialic acid. We demonstrate that both the titer of these ...